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Somasundaram Jayabose Selected Research

2- ((3,5- bis(trifluoromethylphenyl))hydroxymethyl)- 2- (4- nitrophenylamino)- 6- phenyl- 1,2,4a,7a- tetrahydropyrrolo(3,4- b)pyridine- 5,7- dione

9/2008A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells.

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Somasundaram Jayabose Research Topics

Disease

6Neoplasms (Cancer)
05/2015 - 05/2002
5Leukemia
12/2006 - 09/2002
4Hodgkin Disease (Hodgkin's Disease)
04/2016 - 05/2002
3Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
05/2015 - 12/2006
3Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
12/2006 - 01/2004
2Osteosarcoma (Osteogenic Sarcoma)
04/2012 - 12/2008
2Thrombotic Thrombocytopenic Purpura
03/2011 - 05/2003
1Renal Insufficiency (Renal Failure)
05/2015
1Hematologic Neoplasms (Hematological Malignancy)
05/2015
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
05/2015
1Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
05/2015
1Non-Hodgkin Lymphoma (Lymphosarcoma)
05/2015
1Fever (Fevers)
07/2013
1Hemolytic Anemia
07/2013
1Aplastic Anemia (Anemia, Hypoplastic)
07/2013
1Pulmonary Hypertension
07/2013
1acquired Thrombotic thrombocytopenic purpura
07/2013
1Thrombocytopenia (Thrombopenia)
07/2013
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
07/2013
1Neurologic Manifestations (Neurological Manifestations)
07/2013
1Hyperkalemia
12/2008
1Acute Kidney Injury (Acute Renal Failure)
12/2008
1Intracranial Hemorrhages (Intracranial Hemorrhage)
12/2006
1Cytopenia
12/2006
1Central Nervous System Neoplasms
10/2004
1Hemorrhagic Cystitis
10/2004
1Fever of Unknown Origin
10/2004
1Infections
10/2004
1Mucositis
10/2004
1Hemorrhage
01/2004
1Aphasia (Dysphasia)
10/2003
1Edema (Dropsy)
10/2003
1Choledocholithiasis
08/2003
1Cholelithiasis
08/2003
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2003
1Mixed Connective Tissue Disease (MCTD)
05/2003
1Brain Neoplasms (Brain Tumor)
09/2002
1Infertility (Sterility)
05/2002
1Anemia
04/2002
1Abdominal Pain (Pain, Abdominal)
01/2002

Drug/Important Bio-Agent (IBA)

3thiamine triphosphorate (TTP)IBA
07/2013 - 05/2003
3Inosine Triphosphate (ITP)IBA
12/2006 - 01/2004
2Vincristine (Oncovin)FDA LinkGeneric
04/2016 - 05/2003
2Cyclosporine (Ciclosporin)FDA LinkGeneric
07/2013 - 05/2003
2Phosphotransferases (Kinase)IBA
02/2010 - 01/2010
2Methotrexate (Mexate)FDA LinkGeneric
12/2008 - 10/2003
1Doxorubicin (Adriamycin)FDA LinkGeneric
04/2016
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2016
1Prednisone (Sone)FDA LinkGeneric
04/2016
1Etoposide (VP 16)FDA LinkGeneric
04/2016
1Bleomycin (Blenoxane)FDA LinkGeneric
04/2016
1Procarbazine (Matulane)FDA Link
04/2016
1rasburicase (Elitek)FDA Link
05/2015
1Uric Acid (Urate)IBA
05/2015
1Growth Hormone (Somatotropin)IBA
04/2012
1Rituximab (Mabthera)FDA Link
03/2011
110,13- dimethyl- 17- (2- (6- sulfanylidene- 3H- purin- 9- yl)acetyl)- 1,2,6,7,8,9,11,12,14,15,16,17- dodecahydrocyclopenta(a)phenanthren- 3- oneIBA
02/2010
1Nb-(alpha-hydroxynaphthoyl)serotoninIBA
01/2010
1Aspartic Acid (Aspartate)FDA Link
12/2008
1Alanine Transaminase (SGPT)IBA
12/2008
1Tyrosine (L-Tyrosine)FDA Link
09/2008
12- ((3,5- bis(trifluoromethylphenyl))hydroxymethyl)- 2- (4- nitrophenylamino)- 6- phenyl- 1,2,4a,7a- tetrahydropyrrolo(3,4- b)pyridine- 5,7- dioneIBA
09/2008
1DNA (Deoxyribonucleic Acid)IBA
02/2005
1Narcotics (Narcotic Analgesics)IBA
10/2004
1Thiotepa (Triethylenethiophosphoramide)FDA LinkGeneric
10/2004
1Carboplatin (JM8)FDA LinkGeneric
10/2004
1GemcitabineFDA Link
03/2004
1Vinorelbine (Navelbine)FDA LinkGeneric
03/2004
1Cytarabine (Cytosar-U)FDA LinkGeneric
08/2003
1Asparaginase (Elspar)FDA Link
08/2003
1Imatinib Mesylate (Gleevec)FDA Link
06/2003
1Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA
09/2002
1IronIBA
04/2002

Therapy/Procedure

3Therapeutics
04/2012 - 05/2002
2Drug Therapy (Chemotherapy)
12/2006 - 01/2005
1Radiotherapy
04/2016
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
07/2013
1Splenectomy
12/2006
1Craniotomy
12/2006
1Transplantation
10/2004
1Hematopoietic Stem Cell Transplantation
03/2004
1Plasmapheresis
05/2003
1Sphincterotomy
01/2002